Author

Xianchao Zhou

2 papers indexed here

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Oct 2026

Convergent Autoencoder and Machine Learning Methodologies for SARS-CoV-2 Essential Host Factor Identification based on Interferon Pathway Loss-of-Function Perturb-seq Data Mining

The COVID-19 pandemic has highlighted the importance of understanding host-virus interactions, particularly the role of interferon (IFN) signaling pathways in viral pathogenesis. This study employed a comprehensive machine learning framework to analyze Perturb-seq data from SARS-CoV-2-infected Calu-3 respira...

Yu-Sheng Bao, Xian-Chao Zhou, Kai-Yan Feng et al. · Current Bioinformatics · 3 citations

Review Sep 2026

Powering the liver toxicity assessment in the organoid era.

Hepatotoxicity assessment is paramount in drug development and food safety. Traditional in vitro models suffer from insufficient physiological relevance and poor functional reproducibility. Liver organoids have rapidly emerged as three-dimensional culture models capable of recapitulating multicellular interactions and...

Xin-Lan Yu, Ling Shen, Xianchao Zhou et al. · Clinical science · 0 citations