Targeting the H3K4me3-HNRNPC-CD24 Axis Overcomes Stemness and Immunosuppression in Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) is driven by cancer stemness and an immunosuppressive tumor microenvironment, which collectively contribute to therapeutic resistance. While the RNA-binding protein HNRNPC has been implicated in tumor progression, it has primarily been characterized as a downstream effector, and its auton...