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Xiang-Jie Sun

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Open access Aug 2026

Risk assessment of avian influenza A(H5N5) virus from the first human case using the ferret model

The replication kinetics, pathogenesis, and transmission of A/Washington/2148/2025 A(H5N5) virus show that A(H5N5) virus can replicate robustly in mammalian cells and cause severe disease but lacks adaptations supporting efficient airborne spread, informing assessment of the pandemic risk posed by genotype A6 influenza...

J. Pulit-Penaloza, J. Belser, N. Brock et al. · 1 citation
Open access Jul 2026

Cellular tropism of highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses in human respiratory and bovine mammary epithelial cells

Genotype- and cell type–specific differences in replication and host responses are indicated, with B3.3.4.13 showing enhanced tropism in bovine mammary cells, consistent with adaptation that may elevate zoonotic risk, and the value of comparative studies across host cell types and diverse viral isolates to inform risk...

N. Brock, H. Zeng, C. Pappas et al. · 1 citation

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