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Author

Xiang Li

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3 papers indexed here

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Aug 2026

Bifunctional Ionophores for Cuproptosis Activation: Dual Targeting of Copper and Fe-S Protein Homeostasis.

Cellular resilience to therapy often arises from adaptive mechanisms that safeguard iron-sulfur (Fe-S) proteins. Here, we present a rational strategy to overcome such resilience by integrating two synergistic vulnerabilities, copper toxicity and Fe-S cluster homeostasis, into a single molecular scaffold. Inspired by a...

Liuxin Yang, Yiyu Cheng, Si Qin et al. · 0 citations
Review Aug 2026

Rationally Designed Peptides and Peptoids as Inhibitors of Amyloid-β (Aβ) Aggregation

Peptide and peptoid are two types of peptidomimetics can be used as drugs for diseases. One of the main hallmarks in Alzheimer’s Disease (AD) is Aβ aggregation. Due to the natural affinity between peptide and Aβ proteins, peptide therapeutics are found out to be suitable for the disease, as they are almost nontoxic,...

Xiao-Ping Huang, Si-Jie Ma, Xiang Li et al. · 0 citations
Aug 2026

Lipoic acid-conjugated chalcones exert antitumor activity via ROS elevation and ferroptosis.

Overcoming drug resistance and minimizing off-target toxicity remain major challenges in cancer therapy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target. Natural chalcones exhibit antitumor properties linked to oxidative stress indu...

Xin-Yue Bi, Haifu Sun, Kaihong Wang et al. · 0 citations

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