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Open access Sep 2026

AGE-RAGE/NF-κB/SIRT3 signaling cascade is implicated in mitochondrial dysfunction in diabetic gastroparesis

Diabetic gastroparesis is a severe complication of diabetes mellitus, yet its underlying molecular mechanisms remain poorly understood. This study investigated how advanced glycation end products (AGEs) trigger mitochondrial dysfunction through NF-κB activation and SIRT3 suppression in diabetic gastroparesis. We anal...

Peng Zhang, Yao Huang, Ya-Ping Yang et al. · 0 citations
Sep 2026

Salvianic acid A alleviates hepatic fibrosis by inhibiting the AKT1/NF-κB axis.

Hepatic fibrosis (HF) is a crucial and reversible stage, yet there is a paucity of effective clinical antifibrotic drugs. Salvianic acid A (SAA) has shown antifibrotic potential in preliminary studies; however, its molecular mechanisms and potential targets remain incompletely understood. To evaluate the therapeutic ef...

Jin-Qi Hu, Jie-Xin Zhang, Xiao-Mei Ge et al. · 0 citations

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