Xiang-Rong Diao

A systematic transcriptomic atlas and predictive framework for metabolite-driven T cell state transitions

Summary Gut microbial and endogenous metabolites are key regulators at the interface of host metabolism and immunity, yet their global effects on human T cell states remain poorly defined. Here, we profile primary human T cell responses to 364 endogenous and microbiota-derived metabolites using high-throughput digital...