Author

Xiang Ye

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Open access Sep 2026

SERPINB1 as a critical regulator of inflammation and protease activity in human monocytic cells

Abstract SERPINB1, a member of the serpin superfamily, functions primarily as a serine protease suicide inhibitor via its reactive center loop (RCL). While murine studies have elucidated its role in neutrophil homeostasis and survival, the functions and pathways orchestrated by human SERPINB1, particularly in monocytes...

Jareb J. Pérez-Caraballo, Xiang Ye, Jian Cui et al. · ImmunoHorizons · 0 citations

Open access Aug 2026

PKR engages viral RNA and intron-retained host transcripts during poxvirus infection

It is demonstrated that during vaccinia virus infection, PKR binding is enriched on viral RNAs and host-intron-containing transcripts, establishing cooperativity at the intersection of RNA processing, viral replication, and innate defense.

Rui-Lin Zhang, Xiang Ye, Andrew C. Dixson et al. · Cell Reports · 0 citations

Open access Sep 2026

RNA binding proteome profiling reveals RNA-dependent activation of oncogenic host signaling during KSHV infection

A novel strategy by which Kaposi’s sarcoma-associated herpesvirus hijacks RNA-mediated signaling to support its lifecycle is revealed, highlighting the essential role of RNA interactions in viral gene regulation and pathogenesis.

Yang Zhao, Xiang Ye, Madeline Yuen et al. · Nature Communications · 0 citations