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Faecalibacterium prausnitzii attenuates diabetes-associated affective disorders by suppressing neuroinflammation through the SCFAs/FFAR3/NF-κB/NLRP3 pathway.
BACKGROUND Diabetes-associated affective disorders are a global health burden tightly linked to the gut microbiota. The depletion of Faecalibacterium prausnitzii (F. prausnitzii) is a shared feature of diabetes and depression, yet its therapeutic potential and mechanisms remain unclear. METHODS We first analyzed the...
Isolation and genomic analysis of otomycosis pathogens, and genomics-informed antimicrobial peptide design with potential therapeutic applications.
This study establishes an integrated and reproducible workflow that couples clinical isolation and genome resolved characterization of an otomycosis associated A. terreus AT-1 isolate with biosafety aware, mechanism informed triage of phenylalanine based short peptides.