Open access
Sep 2026
Evolutionary and structural pathways of antibody maturation reveal principles for engineering potent SARS-CoV-2 neutralizers
The continual emergence of SARS-CoV-2 variants underscores the need to elucidate antibody maturation and apply rational design principles to optimize therapeutics. This study focused on vaccine-elicited 9C lineage, encoded by IGHV4–34, as a model for affinity maturation and structural refinement. Sequence analyses reve...
Muhammad Waqas Nasir, Qi-Yun Liang, Jing Wang et al.
· Journal of Structural Biolog... · 0 citations