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Xiangtian Shi

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Open access Aug 2026

TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling

Highlights • Integrated TCGA analysis via DESeq2, edgeR, limma & WGCNA identified PBK as key ICC gene.• PBK overexpressed in ICC, correlates with tumor stage.• PBK promotes ICC progression via AKT pathway activation; inhibitor abrogates oncogenic effects.• PBK knockdown suppresses xenograft growth with reduced p-AKT, K...

Xiangtian Shi, Lei Zhang, Tengqi Wang et al. · 0 citations

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