Open access
Aug 2026
Strategy for enhanced production of A40926B0 in Nonomuraea gerenzanensis using an efficient CRISPR/AsCas12f1 system
This work establishes a robust CRISPR editing tool for N. gerenzanensis and provides valuable engineering references for precursor-oriented strain improvement targeting lipoglycopeptide antibiotics, offering insights for the industrial scale production of A40926B0.
Xiao-Ru Wang, Hong-Mei Zhai, Dan-Dan Gu et al.
· Synthetic and Systems Biotec... · 0 citations