Author

Xiao-Chun Zhou

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Open access Sep 2026

Gilteritinib Suppresses Hepatocellular Carcinoma Cells in Association with Reduced Calpain-1 Expression and Inhibition of STAT3/AKT Signaling

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality worldwide, and current targeted therapeutic options remain inadequate. Gilteritinib, a clinically approved tyrosine kinase inhibitor, has shown antitumor activity in hematologic malignancies; however, its therapeutic...

Si-Jing Chen, Yun-Yang Zhao, Yun-Qi Pan et al. · Biomedicines · 0 citations

Open access Aug 2026

Integrating Bulk and Single-Cell RNA Sequencing Identifies and Validates Lactylation-Related Signatures in Acute Kidney Injury

Background: Acute kidney injury (AKI) is a severe clinical syndrome characterized by metabolic stress and profound inflammation. However, the landscape of lactylation-associated molecular alterations and their potential relevance in AKI remain incompletely understood. Methods: Bulk transcriptomes (GSE30718) were analyz...

He-Ping Niu, Zhendong Tian, Ziyi Li et al. · Biomedicines · 0 citations