Xiao-Dan Qu

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

This review delineates the biological functions of the Hippo–YAP/TAZ–TEAD axis and integrate its pathway physiology with the structural basis of druggability, centered on the Ω‐loop surface pocket and the buried palmitoylation‐binding pocket of TEAD, whose distinct geometries dictate the pharmacophoric requirements, pa...