Radiotherapy can convert local tumor injury into systemic antitumor immunity, but this effect depends less on the nominal mode of cell death than on the tissue state that follows irradiation. This narrative review reframes radiation-induced regulated cell death around four functional outputs: antigen preservation, prod...
Xiao-Dong Wang, Wei-Yi Gao, Qian-Qian Wang et al.· Cancer Letters· 0 citations
PD-1/PD-L1 blockade can produce durable tumor control, yet primary, adaptive, and acquired resistance remain common. Existing accounts often catalogue resistance by cellular compartment, obscuring the coordinated nature of tumor adaptation. Here, we introduce immune-pressure redistribution as a treatment-oriented frame...
It is proposed that future progress will depend on ecosystem-matched combinations guided by spatial biomarkers, on-treatment pharmacodynamics, and adaptive trial designs capable of linking mechanism to clinical decision-making.
