Nucleases are crucial for various bacterial processes, including genome maintenance and host defense. Deoxydinucleases (diDNases), a class of Gram-positive bacteria–specific nucleases associated with mobile genetic elements, are homologous to nanoRNase C (NrnC) in Gram-negative bacteria but exhibit notable differences:...
Sofia Mortensen, Audrey A. Burnim, K. Dufault-Thompson et al.· Science Advances· 0 citations
This work introduces LAMBDA, a benchmark designed to rigorously evaluate genome language model embeddings through phage-bacteria sequence discrimination across four categories of increasing complexity: probing tasks, fine-tuning assessments, diagnostic tests, and genome-wide prophage detection.
LeAnn M. Lindsey, Nicole L. Pershing, K. Dufault-Thompson et al.· NAR Genomics and Bioinformat...· 0 citations
The structure reveals for the first time the interaction between a biofilm exopolysaccharide and matrix protein, as well as insights into conformational changes of exopolysaccharide induced by this binding, and provides a generalizable approach for studying the biophysical and biochemical properties of carbohydrate-dep...
Alex Hinbest, Hyerim Bianca Nam, E. Liszczyk et al.· bioRxiv· 0 citations
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