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Xiao-Fang Zhang

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Open access Oct 2026

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

ABSTRACT Acquired resistance to gemcitabine (GEM) remains a major barrier to effective treatment of pancreatic ductal adenocarcinoma (PDAC). Here we identify histone H3K18 lactylation (H3K18la), induced by GEM‐driven lactate accumulation, as a key epigenetic mechanism of chemoresistance. H3K18la functions as a transcri...

Li-Jun Zhao, Jian-Zhong Cao, Wen-Yue Liu et al. · 0 citations
Jul 2026

p53 hotspot mutants attenuate CTL-mediated tumor cell killing through a novel ALKBH5-YTHDF3-PD-L1 pathway

It is found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment, and restoration of ALKBH5 activation or inhibition of the m6A modification-YTHDF3 axis could potentially reactivate immune surveillance and eliminate tumors harboring mut-p53.

Zhuan Ju, Xiang Zhang, Wen-Jie Zuo et al. · 0 citations

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