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Xiaofei Guo

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Open access Aug 2026

A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traits

Non-coding regulatory variation drives complex traits, domestication, and evolutionary adaptation, yet the sheep genome lacks high-resolution functional annotation. Here we present SheepEpimap, a multi-tissue regulatory atlas harmonizing 516 CUT&Tag histone modifications, ATAC-seq, and RNA-seq datasets across 43 adult...

Zhu Meng, Shiwen Zhang, Zi-Yang Zhuang et al. · 0 citations
Open access Aug 2026

LNC_003296 regulates the proliferation and differentiation of ovine myoblasts by modulating the stability of Hsp70

Abstract Long non-coding RNAs (lncRNAs) are involved in various regulatory processes during muscle development. Our previous RNA-seq study identified LNC_003296 as being significantly differentially expressed between ovariectomized Small-tailed Han sheep (OR-STH) and their non-ovariectomized counterparts (STH). Through...

Yize Song, Xiaofei Guo, Xiaosheng Zhang et al. · 0 citations

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