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Xiao-Feng He

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Sep 2026

Deoxycalyxin A exerts hypoglycemic effects through activating TGR5-induced GLP-1 secretion via TGR5/PKA/MEK/ERK pathway.

Type 2 diabetes mellitus (T2DM) is a heterogeneous metabolic disorder characterized by insulin resistance and progressive β cell dysfunction. Deoxycalyxin A (DCA), a unique diarylheptanoid-chalcone hybrid isolated from Alpinia katsumadai, was identified as a novel stimulator of GLP 1 secretion in both STC-1 (EC50: 10.7...

Sheng-Li Wu, Xiao-Feng He, Pianchou Gongpan et al. · 0 citations

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