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Xiao-Feng Ji

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Open access Sep 2026

Integrated Single-Nucleus and Epigenomic Profiling Reveals Coordinated Neuro-Glial and Chromatin Remodeling in the Type 2 Diabetic Hypothalamus

Highlights What are the main findings? • Integrated single-nucleus transcriptomic and tissue-level chromatin accessibility profiling identifies coordinated neuronal, oligodendrocyte-lineage, and regulatory remodeling in the hypothalamus of an HFD/STZ-induced T2D mouse model.• Multi-omic evidence highlights activation o...

Shuo-Yang Zhao, Sheng-Wei Sui, Xin Guo et al. · 0 citations

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