Xiao-Feng Zheng

Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation.

Psoriasis is a complex inflammatory disease associated with keratinocyte hyperproliferation, abnormal differentiation, and hyper-inflammation. Recent advances have indicated that oxidative stress and ferroptosis contribute to the development of this pathology; however, the regulation of their mechanisms remains unclear...