Integrative single-cell and bulk transcriptomics define polyamine-associated cell states in acute myeloid leukemia and implicate CCT6A in polyamine homeostasis
Background Polyamine metabolism is an important metabolic dependency in cancer, but its cellular organization and clinical relevance in acute myeloid leukemia (AML) remain unclear. Methods We integrated publicly available single-cell RNA sequencing (scRNA-seq) data from 41 AML samples (198,846 cells) and bulk transcrip...