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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xiao-Hua Wu

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Open access Oct 2026

NONO mitigates transcription-replication conflicts during replication stress by restraining BRD4-dependent transcription elongation.

Transcription-replication conflicts (TRCs) drive genomic instability and are linked to tumorigenesis and treatment response. Replication stress exacerbates TRCs, but how cells coordinate transcription and replication to limit these conflicts remains unclear. Here, we identify NONO as a key regulator that maintains tran...

Wen-Chi Wu, Cheng-Yan Ding, Jia-Meng Ma et al. · 0 citations

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