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Author

Xiao Huang

h-index 12 View on Semantic Scholar

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Aug 2026

T-cell immunosenescence limits CD19 CAR T-cell function in chronic lymphocytic leukemia.

Ibrutinib improved proliferative fitness, attenuated senescence-associated features and SASP output in paired patient and direct-exposure assays, and enhanced CAR T-cell expansion in an ibrutinib-resistant CLL model.

Julia Han Noll, Devin Dersh, Jiang-Yuan Li et al. · 0 citations
Review 2026

Manufacturing as biology: How T-cell processing shapes therapeutic outcomes.

This review underscores that optimizing T-cell therapy requires treating manufacturing not as a logistical necessity but as a controllable biological intervention, and a mechanistic understanding of how processing decisions program cellular behavior will enable the rational design of more potent, durable, and scalable...

Nikolai Przybylski, Qing-He Zeng, Xiao Huang · 0 citations

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