Xiao-Jie Han

Tyr–Mpa Proximity-Induced Atypical tert-Butyl Intramolecular Migration in Desmopressin: Mechanistic Elucidation of a Site-Selective Impurity and Its Suppression Strategy

Desmopressin, a synthetic analog of vasopressin widely used in the treatment of diabetes insipidus and bleeding disorders, is a representative disulfide-containing peptide therapeutic prepared by Fmoc-based solid-phase peptide synthesis (SPPS). Its unique sequence architecture, particularly the spatial proximity betwee...