Author

Xiao-Jun Huang

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Sep 2026

NK3 subsets are linked to NK cell exhaustion and immunotherapy responsiveness in tumor.

Natural killer (NK) cells constitute the first line of human immune defense. They have attracted extensive research in the field of tumor immunity owing to their potent cytotoxicity, robust cytokine secretion, and immunomodulatory capacity. However, chronic tumor antigen exposure would induce exhaustion in NK cells (NK...

Zi-Xuan Gou, Yu-Tong Bao, Li-Hong Liu et al. · Seminars in Oncology · 0 citations

Open access Sep 2026

Single-cell mapping of thymus-dependent naïve t-cell regeneration reveals CD61-associated states after hematopoietic stem cell transplantation

Thymus-dependent de novo T-cell generation is essential for maintaining T-cell diversity and immune competence. Although thymic involution after puberty reduces thymic output, residual thymic function remains important for immune surveillance and immune reconstitution following hematopoietic stem cell transplantation (...

Fangqing Zhang, Xinya Jiang, Shuang Fan et al. · Experimental Hematology & On... · 0 citations

Review Jul 2026

Deciphering CD8+ T Cell Exhaustion in Human Cancers Through Single-Cell and Spatial Transcriptomics.

This review summarizes recent advances in high-resolution omics technologies for precisely dissecting Tex heterogeneity, functional features, and interactions with other cells, and emphasizes the central value of optimizing Tex-targeted tumor immunotherapy strategies.

Zi-Xuan Gou, Xiao-Jun Huang, Xiang-Yu Zhao · Cancer Letters · 0 citations