Chemotherapy (CT) suffers from poor selectivity and systemic toxicity, while photodynamic therapy (PDT) and photothermal therapy (PTT) are inherently limited by tumor hypoxia and thermoresistance. Herein, we develop a trimodal synergistic nanoplatform (PDM-BDP NPs) for ovarian cancer treatment by integrating PDT, mild...
Jia-Qi Wang, Jie Zhang, Dong-Ping Xu et al.· Advanced Healthcare Material...· 0 citations
Idiopathic pulmonary fibrosis (IPF) is a progressive refractory lung disorder with limited effective therapies. Although RNA interference (RNAi) holds promise for IPF treatment, current delivery systems are hampered by complex preparation, redundant components, and an inability to modulate oxidative stress, which sever...
Yuxin Yang, Hua Zhang, Jian-Jun Du et al.· Advances in Materials· 0 citations
Photodynamic antimicrobial therapy (PDAT) offers a promising bactericidal strategy via light-triggered reactive oxygen species (ROS), yet conventional photosensitizers (PSs) typically lack sustained inhibitory activity. Herein, we attempt to redefine the functionality of PSs through a consensus-assisted design strategy...
A triple‐stage precision nanogel platform in which carbon dots serve as organelle‑targeted delivery vehicles that achieved over 85% tumor growth inhibition with minimal systemic toxicity and offers a promising strategy to overcome key barriers in cancer therapy.
Yunxiao Zhang, Jianwei Li, Lei Yue et al.· Advanced Healthcare Material...· 0 citations
This work provides an oxygen-unrestricted synergistic strategy to compensate for the limitations of standalone Type II PSs or HAPs monotherapy, offering valuable insights for clinical cancer treatment.
