Sep 2026
METTL3-m6A-IGF2BP2 Axis-Mediated Stabilization of MTFR1 Promotes Glycolytic Reprogramming in Colorectal Cancer.
BACKGROUND Metabolic reprogramming fuels colorectal cancer (CRC), yet upstream regulators that lock cells into a glycolytic state remain incompletely defined. METHODS We integrated single-cell and spatial transcriptomics with GWAS-eQTL-Mendelian randomization to nominate CRC-associated candidate genes, and profiled t...
Li-Qiang Wei, Deng-He Liu, Chun-Yu Lin et al.
· Journal of Gastroenterology... · 0 citations