Author

Xiaokang Jin

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Open access Sep 2026

PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery

Massive library-based platforms enable rapid early hit discovery, yet subsequent hit resynthesis and validation remain major bottlenecks in drug discovery. This delay is amplified when optimizing hits, or elaborating structures towards more advanced modalities, such as chemical inducers of proximity (CIPs). Here, we re...

Sean M. McKenna, Monika Gnatzy, Edith van der Nol et al. · bioRxiv · 0 citations

Open access Jul 2025

Expanding the repertoire of chemically induced covalent neoantigens

The ubiquitin-proteasome system generates peptide fragments that are displayed on MHC-I molecules. Recent studies revealed that covalent small molecules can hijack this process, leading to the presentation of hapten-modified peptide fragments, or covalent neoantigens. Here, we report a chemical proteomics platform to s...

Chen Zhou, Wei Huang, Xiaokang Jin et al. · bioRxiv · 0 citations