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Xiao-Lei Zhu

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Aug 2026

Structure-Based Discovery of Trifluoromethyl Oxadiazole Oxime Ethers as Potent Histone Deacetylase Inhibitors.

Histone deacetylases (HDACs), well-established epigenetic targets in medicinal chemistry, have recently attracted attention as potential targets for fungicides against phytopathogenic fungi. In this study, EX-3, a known trifluoromethyl oxadiazole (TFMO)-based HDAC inhibitor, was selected as a lead compound. Guided by i...

Shuyu Dong, Fang Qin, Zong-Wei Lu et al. · 0 citations

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