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Xiao-Li Wang

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Open access Aug 2026

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

ABSTRACT Shiga toxin‐producing Escherichia coli (STEC) infections cause severe systemic complications, yet targeted antitoxin therapeutics remain an unmet clinical need. Here, we isolated a panel of human monoclonal antibodies (mAbs) targeted at STEC toxin and characterized two potent neutralizing candidates, RDS045 an...

Jianting Ke, Xin Li, Xiao-Li Wang et al. · 0 citations

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