Open access
Sep 2026
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death.
TNF can activate both prosurvival and prodeath signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound complex I, while death signaling is driven by cytosolic complex II. Receptor-interacting protein kinase 1 (RIPK1) is a central component of...
Hao-Hao Lu, Tong-De Du, Lin Li et al.
· Nature Structural & Molecula... · 0 citations