The PGC-1α-ferroptosis axis mediates empagliflozin-induced epithelial barrier protection in sepsis-associated acute lung injury.
Sepsis-associated acute lung injury is characterized by epithelial barrier failure, excessive oxidative stress, and inflammatory tissue damage. Ferroptosis has emerged as an important mechanism linking lipid peroxidation to epithelial dysfunction, but the regulatory mechanisms governing ferroptosis resistance in sepsis...