Xiao-Min Li

[Efficient production of l- lysine by Escherichia coli through systems metabolic engineering].

Synthetic Carbon-Efficient Pathway and Programmable Microenvironment for Sustainable Caffeic Acid Production

Microbial production of phenolic acids offers a sustainable alternative to plant extraction, reducing carbon loss and environmental impact. Here, we present a multi-level engineering strategy in Escherichia coli integrating carbon-efficient pathways, enzyme optimization, and subcellular compartmentalization. A synthe...

[Construction of an integrative recombinant Escherichia coli strain for efficient biosynthesis of chondroitin].

Reprogramming energy system for growth and bioproduction from CO₂ and methanol in Escherichia coli

Microbial CO₂ assimilation provides a strategy for sustainable biomanufacturing. However, CO₂ reduction requires substantial energy input, while native energy systems are tightly regulated and extensively consumed by endogenous metabolism, limiting assimilation efficiency. Here, we design and construct an orthogonal en...

From laboratory to industry: Systematic approaches to the biomanufacturing of short-chain diols.

Short-chain diols (C2-C6) are key platform chemicals widely used in polyesters and polyurethanes; however, their large-scale adoption remains limited by cost, scalability, and process robustness. This review summarizes recent advances in microbial production from an integrated perspective encompassing chassis engineeri...