Author

Xiao-Min Yu

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Open access Sep 2026

Cytotoxic lymphocyte death drives monocyte activation and TNF/IFN-γ synergism in TBK1 deficiency

Combined TNF and JAK inhibition as an effective therapeutic strategy for TBK1 deficiency is supported and cytotoxic lymphocytes are the primary drivers of aberrant cell death through a T cell-myeloid axis dependent on TNF/IFN-γ synergism.

Xu Han, Jialin Dai, Ji-Hong Xiao et al. · Cell Death & Disease · 0 citations

Jul 2026

A Multi-Center Integrative Cohort Characterizing the Genetic, Clinical, and Transcriptomic Features of ACP5 Deficiency.

An upregulated interferon signature was revealed, and monocytes were identified as a major cellular source of inflammation in patients with SPENCDI, expanding the genetic and clinical spectrum of ACP5 deficiency.

Shiling Zhong, Shuang-Yue Ma, Y. El Chazli et al. · Arthritis & Rheumatology · 0 citations