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Author

Xiaonan Dong

2 papers indexed here

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Open access Sep 2026

Zinc mediates the allosteric activation of Shiftless to suppress programmed -1 ribosomal frameshifting.

Many medically important viruses, including HIV-1 and severe acute respiratory syndrome coronavirus 2, utilize programmed -1 ribosomal frameshifting (-1 PRF) to synthesize certain proteins essential for the viral life cycle. Shiftless (SHFL) is an interferon-simulated, zinc finger-containing protein that restricts -1 P...

Shi-Ting He, Yong-Feng Zheng, Ru-Hong Ying et al. · 0 citations
Open access Jul 2026

Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development

Summary The cerebellum relies on Purkinje cells (PCs) to coordinate motor functions and maintain neural circuitry. Impaired PC dendritogenesis is linked to neurological disorders, yet intrinsic molecular mechanisms remain unclear. We demonstrate that postnatal deletion of Yin Yang 1 (Yy1) in PCs disrupts dendrite and s...

Y. Lui, Xiaonan Dong, T. C. Leung et al. · 0 citations

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