Exploratory analysis of transcriptionally active HBV-host chimeric transcript burden in patients with increasing HBsAg during long-term antiviral therapy.
BACKGROUND AND AIMS The longitudinal relationship between transcriptionally active hepatitis B virus (HBV) integration dynamics and serum hepatitis B surface antigen (HBsAg) during long-term antiviral therapy remains unclear. METHODS Patients with HBV-related fibrosis/cirrhosis who underwent at least one liver biopsy...