FABP3 regulates vascular remodeling and endothelial-mesenchymal transition through NF-κB activation in aged mice fed a high-fat diet.
BACKGROUND Aging and obesity synergistically promote pathological vascular remodeling mediated by endothelial-mesenchymal transition (EndMT). Fatty acid-binding protein 3 (FABP3) maintains fatty acid homeostasis and cardiovascular function; however, its role in EndMT-driven vascular remodeling under combined aging and...