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Xiao-Qi Chen

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Sep 2026

Cu/TEMPO-Catalyzed Direct C2-Quaternization of Pyridines with Aldehydes via Sequential N–N Bond Formation and Cleavage

Pyridine represents an indispensable class of nitrogen-containing heteroarene, yet regioselective construction of an all-carbon quaternary center at the C2 position has remained a longstanding synthetic challenge. Here, we report a Cu/TEMPO-catalyzed regioselective C2 quaternization of pyridines with readily availabl...

Amu Wang, Xiao-Qi Chen, Tong Liu et al. · 0 citations

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