Author

Xiao-Qing Cheng

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Open access Sep 2026

Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 Dependency

Cancer genomics studies have implicated combined loss of VHL and TSC1 as sufficient to initiate clear cell renal cell carcinoma (ccRCC) in humans. Here, we engineered a mouse model with kidney-specific deletion of Vhl and Tsc1. VhlF/FTsc1F/FKsp-Cre+mice developed multifocal renal cell carcinomas starting at 7 weeks of...

Jia-Ning Xu, Xiao-Qing Cheng, O. A. Aboud et al. · bioRxiv · 0 citations

Open access Aug 2026

PACM-01 RECEPTOR-COMPLEX–SPECIFIC CD200 ACTIVATION RECEPTOR TARGETING DRIVES COMPARTMENT-SPECIFIC ANTI-TUMOR IMMUNITY IN BREAST CARCINOMA

This work establishes receptor-complex–specific CD200AR targeting as a strategy to generate spatially tailored antitumor immunity and supports further translational development of ARL200-based combination therapies for metastatic breast carcinoma involving the CNS.

S. Frederico, R. Bose, Lindsey Sloan et al. · Neuro-Oncology Advances · 0 citations