Xiao-Qing Tang

miR-483 deficiency promotes loss of pancreatic beta-cell identity and aberrant glucagon production under metabolic stress.

Pancreatic β-cell dedifferentiation is a pathological mechanism that contributes to β-cell dysfunction and loss during type 2 diabetes (T2D), but the underlying mechanisms remain incompletely understood. MicroRNAs (miRNAs) are key post-transcriptional regulators of cellular identity and function. We previously identifi...