Author

Xiao-Qing Zhu

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Review Open access Sep 2026

Methimazole-induced agranulocytosis complicated by sepsis and ileocolic intussusception: a case report and literature review

Methimazole (MMI) is a primary pharmacological treatment for autoimmune thyrotoxicosis, but it carries a risk of agranulocytosis—a rare yet severe adverse effect that can lead to life-threatening infections due to profound immunosuppression. This case report aims to present and analyze an unusual instance of MMI-...

Xiao-Qing Zhu, Huan-Gai Zhang, Ji-Min Lin et al. · BMC Endocrine Disorders · 0 citations

Open access Aug 2026

Synthesis of Aminoacyl-2-Cyanopyrrolidine Compounds and Their Inhibitory Effect on the DPP-4 Enzyme.

BACKGROUND Diabetes mellitus is a major global health concern. DPP-4 (dipeptidyl peptidase-4) inhibitors containing a 2-cyanopyrrolidine scaffold are in clinical use; however, systematic evaluation of amides derived from amino acids adjacent to the N-2 position of GLP-1 (glucagon-like peptide-1) has not been reported....

Li-Yuan Guo, Man Di, Zhi-Yan Dong et al. · Pharmazie · 0 citations