USP36-mediated stabilization of NAT10 promotes osteosarcoma progression via ac4C-dependent KIF23 mRNA stabilization.
Osteosarcoma is an aggressive bone malignancy with a propensity for pulmonary metastasis, yet the molecular mechanisms linking protein homeostasis to epitranscriptomic regulation remain incompletely understood. Here, integrated transcriptomic, survival, protein-interaction, and CRISPR dependency analyses identified the...