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Xiao-Shan Xiong

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Review Open access Sep 2026

Cognitive Behavioral Therapy and Pain Chronification: Neuroimmune Rationale, Evidence Boundaries, and Trial Design Priorities: A Structured Narrative Review

Background Pain chronification is a dynamic transition in which persistent pain may be shaped by interacting nociceptive, peripheral, spinal, supraspinal, neuroimmune, endocrine and cognitive-affective processes. Cognitive Behavioral Therapy (CBT) has clinical value in chronic pain, but claims about glial modulation an...

Ying-Ze Xi, Tian-Qi Zhang, Xing-Wei Zhao et al. · 0 citations

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