Author

Xiao-Tian Han

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Open access Sep 2026

DUSP8 Ameliorates Podocyte Mitochondrial Dysfunction via PRAS40 Dephosphorylation in Diabetic Kidney Disease.

Mitochondrial dysfunction is central to podocyte injury in diabetic kidney disease (DKD). Here, we observed consistent downregulation of dual-specificity phosphatase 8 (DUSP8) in glomeruli from patients with DKD, db/db mice, STZ/HFD-induced DKD mice, and high glucose-treated podocytes. Glomerular DUSP8 levels were posi...

Yue Liu, Jiangong Lin, Bao-Ze Ma et al. · Free Radical Biology & Medic... · 0 citations

Open access Sep 2026

S100A1 Promotes MDM2‐Mediated KLF15 Ubiquitination to Regulate ID1‐Driven Tubular Injury in Diabetic Kidney Disease

Comparison of single‐cell RNA sequencing data of kidney samples from healthy controls and DKD patients reveals a novel S100A1‐MDM2‐KLF15‐ID1 regulatory axis in DKD pathogenesis and suggests targeting S100A1 might be a potential therapy for proximal tubular injury in DKD.

Zhi-Tao Zeng, Jia-Zhen Shang, Shou-Yu Chai et al. · The FASEB Journal · 0 citations