Author

Xiaotong Song

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Open access Oct 2026

Metabolic Rewiring of GPC3-Targeted CAR T Cells Expressing IL-15 and HER2-Targeted CAR T Cells via the ADA1–CD26 Axis Promotes Tumor Infiltration and Limits Systemic Toxicities

Background: Chimeric antigen receptor (CAR) T-cell therapy for solid tumors is limited by inadequate T-cell persistence and tumor infiltration, as well as treatment-associated cytokine release syndrome (CRS). To address these challenges, we developed a metabolically rewired CAR T-cell (MRCAR) platform by co-expressing...

Yue Hu, Kevin Song, Ruo-Ning Wang et al. · Biomedicines · 0 citations

Open access Aug 2026

Genome-Wide Integration Site Profiling of Multi-Component CAR T-Cell Engineering Systems with ADA1/CD26 Co-Transduction

This study provides the first comprehensive, genome-wide characterization of retroviral integration site profiles in CAR T-cell products manufactured by multi-vector co-transduction with an ADA1/CD26 module and establishes a reference framework for integration site monitoring in next-generation CAR T-cell engineering s...

Kevin Song, Yue Hu, Xiao-Tong Song · Biomedicines · 0 citations