Xiao-Wei Zhang

Redirecting Regioselectivity in Cytochrome P450 ApPT for B-Ring Functionalization of Pentacyclic Triterpenoids.

Pentacyclic triterpenoids (PTs) feature a steroid-like privileged scaffold, but late‑stage functionalization of their inert B‑ring C(sp3)─H bonds remains a formidable synthetic challenge due to the absence of directing groups and the consequent poor regio- and stereoselectivity. Here we report a semi-rationally enginee...