Xiao-Wen Zhao

Neurofilament impairment in neurodegenerative diseases: pathogenesis, biomarkers and diagnostic values

Neurofilament (NF) proteins, as integral components of the neuronal cytoskeleton, are essential for maintaining axonal structure and function. Genetic defects, aberrant post-translational modifications, and co-aggregation with other pathogenic proteins can disrupt NF homeostasis, leading to axonal injury and neuronal d...