Crosstalk between innate immune signaling pathways and integrated TLR, NLRP3 inflammasome, cGAS–STING, and NF-κB networks in sepsis
This review comprehensively examines the molecular architecture and dynamic interactions among these signaling networks, highlighting the shared adaptor proteins, regulatory feedback loops, and signaling hubs that determine the transition from protective host defense to uncontrolled hyperinflammation and subsequent imm...