ER+ (estrogen receptor positive) breast cancer is the most common subtype of breast cancer, for which endocrine therapy is the primary treatment. However, the development of drug resistance severely limits the clinical efficacy. In recent years, lipid metabolism reprogramming, as a key metabolic feature of tumor cells...
Zhi-Qi Sui, Xiao-Xi Han, Shao-Chun Liu et al.· Frontiers in Oncology· 0 citations
A candidate biomarker-informed framework that integrates tumor-cell escape with cytokine, immune, stromal, vascular, and metabolic remodeling and summarizes emerging therapeutic strategies is proposed, providing a translational basis for testing state-informed and sequence-aware therapeutic strategies.
Yu-Han Tang, Ying-Ze Zhu, Shao-Chun Liu et al.· Frontiers in Immunology· 0 citations
An integrative stromal-checkpoint framework is used to describe stromal programs that couple extracellular matrix remodeling, metabolic stress, vascular dysfunction, and immune exclusion into treatment-resistant tumor ecologies and discusses how ADAM12-informed biomarkers, spatial barrier profiling, and stromal-priming...
Shao-Chun Liu, Jian Xu, Han Zhang et al.· Cell Communication and Signa...· 1 citation
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