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Xiao-Xi Jia

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Open access Aug 2026

Estimating the Penetrance of PRNP Mutations in Chinese Prion Disease Patients based on the Genome Databases.

Genetic prion diseases (gPrDs) are directly caused by mutations in the prion protein gene (PRNP). Although several mutations have been strongly linked to disease manifestation, the penetrance of many variants remains uncertain. This study aimed to clarify the penetrance of PRNP variants by analyzing data from the Chine...

R. A, Xiao-Xi Jia, Dong-Hua Zhou et al. · 0 citations
Jul 2026

Elevation of Beta-2 Microglobulin during Prion Infection is Closely Correlated with PrPSc Accumulation and is Independent of MHC-I.

β2-microglobulin (B2M) is implicated in neuroinflammatory and neurodegenerative processes, but its role in prion diseases remains unclear. Here, the alterations in B2M expression and distribution as well as its correlation with PrPSc accumulation were investigated in several scrapie-infected rodent models and a prion-i...

Xiao-Xi Jia, Bing Xu, Chao Hu et al. · 0 citations

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